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Related Concept Videos

The Nucleus01:32

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
What are Cells?01:07

What are Cells?

Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
What are Cells?01:15

What are Cells?

Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium, or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
What are Cells?01:15

What are Cells?

Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium, or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...

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Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques
09:48

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques

Published on: June 30, 2017

Features for cells and nuclei classification.

Song Liu1, Piyushkumar A Mundra, Jagath C Rajapakse

  • 1BioInformatics Research Centre, School of Computer Engineering, Nanyang Technological university, Singapore. y060101@e.ntu.edu.sg

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|January 19, 2012
PubMed
Summary
This summary is machine-generated.

Automated cell image analysis relies on cell features. This study identified Zernike moments, Daubechies wavelets, and Gabor wavelets as optimal features for classifying cells and cell nuclei in microscopy images.

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Area of Science:

  • Biomedical imaging
  • Computational biology
  • Image analysis

Background:

  • Automated analysis of cellular images is crucial for biological research.
  • The performance of such systems depends significantly on the extracted features.
  • Identifying optimal features is key to improving classification accuracy.

Purpose of the Study:

  • To explore an exhaustive set of features for cell and cell nuclei classification.
  • To determine the optimal subset of features for accurate image analysis.
  • To identify which feature types are most effective for fluorescent microscopy images.

Main Methods:

  • Extraction of a comprehensive set of morphological, topological, and texture features.
  • Application of popular feature selection methods to identify the most informative features.
  • Evaluation of feature importance for cell and cell nuclei classification tasks.

Main Results:

  • Feature selection identified a subset of optimal features.
  • Zernike moments, Daubechies wavelets, and Gabor wavelets were found to be highly significant.
  • These wavelet and moment-based features are critical for accurate cell classification.

Conclusions:

  • The choice of features critically impacts automated cellular image analysis.
  • Zernike moments and wavelet transforms (Daubechies, Gabor) provide superior features for cell and nuclei classification.
  • These findings can guide the development of more effective image analysis tools.