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Post-ovulatory contraception.

A Glasier, D T Baird

    Bailliere'S Clinical Obstetrics and Gynaecology
    |June 1, 1990
    PubMed
    Summary
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    New contraceptive methods aim to prevent pregnancy by interfering with implantation. Research explores antigestagens and antioestrogens as potential side-effect-free options for post-coital contraception.

    Area of Science:

    • Reproductive endocrinology and contraception research.

    Background:

    • Current emergency contraception methods include intrauterine devices (IUCDs) and post-coital contraceptive steroids.
    • IUCDs may prevent implantation by stimulating endometrial prostaglandins.
    • High-dose estrogens have significant side effects and a 72-hour limit.

    Purpose of the Study:

    • To explore novel approaches for preventing pregnancy after unprotected intercourse.
    • To investigate the potential of antigestagens and antioestrogens as post-coital contraceptives.
    • To identify methods that interfere with early embryo implantation or survival.

    Main Methods:

    • Reviewing existing knowledge on hormonal and intrauterine contraception mechanisms.
    • Evaluating the efficacy of antigestagens and antioestrogens in creating a uterine environment unfavorable for implantation.
    Keywords:
    BehaviorBiologyCoital FrequencyContraceptionContraceptive AgentsContraceptive Agents, EstrogenContraceptive Agents, FemaleContraceptive Agents, PostcoitalContraceptive Agents, ProgestinContraceptive EffectivenessContraceptive MethodsContraceptive Mode Of ActionCorpus LuteumDiethylstilbestrolEndocrine SystemEstradiolEstrogenic Substances, ConjugatedEstrogensEthinyl EstradiolFamily PlanningGenitaliaGenitalia, FemaleHormone AntagonistsHormonesImplantation SuppressionIudIud, Copper ReleasingLevonorgestrelLiterature ReviewLuteolytic EffectsNorethindroneOral ContraceptivesOral Contraceptives, CombinedOvaryOvulation SuppressionPhysiologyProstaglandinsProstaglandins, SyntheticRu-486Sex BehaviorUrogenital System

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  • Considering the luteolytic potential of agents targeting the corpus luteum.

    • Main Results:

    • Antigestagens and antioestrogens show promise for preventing implantation.
    • Combining antigestagens with prostaglandins is effective for early pregnancy termination.
    • Targeting the corpus luteum with luteolytic agents could dislodge implanting embryos.

    Conclusions:

    • Developing novel, side-effect-free methods to prevent implantation is a key goal.
    • Antigestagens, antioestrogens, or luteolytic agents could offer new regular contraception options.
    • Future research should focus on safe and effective anti-implantation strategies.