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Related Experiment Video

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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells
15:41

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Micro-sized syringes for single-cell fluidic access integrated on a micro-electrode array CMOS chip.

Roeland Huys1, Dries Braeken, Liesbeth Micholt

  • 1Imec, Bio-Electronic Systems Group, Kapeldreef 75, 3001 Leuven, Heverlee. huys@imec.be

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|January 19, 2012
PubMed
Summary

Researchers developed a novel CMOS chip with micro-syringes and electrodes for automated cell analysis. This platform enables precise substance delivery and advanced in vitro cell examination for future research.

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Area of Science:

  • Biotechnology
  • Microfluidics
  • Electrical Engineering

Background:

  • Advancements in very-large scale integration (VLS I) and micro-machining have spurred the creation of innovative in vitro cell and tissue examination platforms.
  • Automated and advanced analysis methods are crucial for modern biological and medical research.

Purpose of the Study:

  • To present a novel CMOS chip integrating micro-syringes and micro-nail electrodes for advanced in vitro cell studies.
  • To demonstrate the chip's capability for localized substance delivery and potential for planar patch clamping.

Main Methods:

  • Design and fabrication of a CMOS chip using 0.18 μm technology with integrated micro-syringes and micro-nail electrodes.
  • Utilizing through-wafer micro-fluidic channels (1 μm inner diameter) for addressing individual micro-syringes.
  • Demonstrating micro-fluidic functionality via fluorescent species diffusion.
  • Culturing hippocampal neurons on the chip and analyzing cell-chip interface using focused ion beam-scanning electron microscopy (FIB-SEM).

Main Results:

  • Successful demonstration of micro-fluidic access and substance diffusion through the micro-channels.
  • Observation of hippocampal neuron protrusion into micro-syringe channels, forming a strong cell-membrane-chip interface.
  • Validation of the chip's potential for localized delivery and advanced electrophysiological recordings.

Conclusions:

  • The developed CMOS chip represents a significant advancement in automated in vitro cell analysis platforms.
  • The integrated micro-fluidic and electrode system offers a novel approach for precise cellular manipulation and investigation.
  • This technology paves the way for future automated platforms enabling targeted substance delivery and advanced patch clamping techniques.