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Updated: May 25, 2026

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
[Study on rat nasal absorption in situ of borneol based on single pass perfusion method]
Xiao Song1, Shouying Du, Yang Lu
1School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. songxiao1999@sohu.com
Objective:
To investigate the absorption characteristic of borneol.
Method:
Using single pass perfusion model, the active ingredient of borneol were detected by GC. The drug concentration, perfusion rate and pH value on the absorption of borneol were studied.
Result:
Perfusion rate on the absorption rate constants (Ka) had significant effects. Drug concentration and pH value on the absorption rate constants had no significant impact.
Conclusion:
the absorption of borneol is good by nasal. The absorption rate constants of borneol have no effected by drug concentration. The absorption of borneol is via a simple diffusion.
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