Related Experiment Video
Updated: May 25, 2026

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
Published on: March 15, 2024
Partial motor restoration upon administration of sildenafil: a case study
1Clinical Rehabilitation Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA. ninoter@aol.com
Objective:
Extensive research in the past decade has confirmed that the adult brain maintains some plasticity, including neural cell birth, migration and integration. Pre-clinical data strongly suggest that phosphodiesterase type 5 (PDE5) inhibitors promote cerebral neovascularization and neurogenesis. Animal studies of cerebral stroke suggest potential regenerative benefits following treatment with sildenafil citrate, a PDE5 inhibitor. This study reports a case in which compassionate use of sildenafil was investigated as a treatment to improve physical functioning, more than 4 decades after development of spastic quadriplegia during the 1st-2nd year of life.
Methods:
Sildenafil 100 mg was administered every 24 hours for 7 months.
Results:
Sildenafil treatment was associated with clinical (functional) improvement.
Conclusions:
The activity of sildenafil on cerebral neovascularization and neurogenesis may be the mechanism for the observed functional benefits.
Related Concept Videos
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Male Sexual Response: Erection & Ejaculation
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Antihypertensive Drugs: Vasodilators
