Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Development of the Lymphatic System

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Lymphatic Vessels and Lymph Transport

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mantis flap for reconstruction of large full-thickness lower lip defects.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026

Same author

The resurgence of whole blood transfusion: Evaluating microcirculatory evidence in hemorrhagic trauma care: A review.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2026

Same author

Clinical Features of Hidradenitis Suppurativa in Down Syndrome Patients: A Multicenter Spanish Study.

Journal of cutaneous medicine and surgery·2026

Same author

Increased Healthcare Utilization in Hidradenitis Suppurativa and Arthritis: A Propensity Score-Matched Analysis from a Hospital-Based Cohort.

Skin appendage disorders·2026

Same author

Sex determines cardiac and renal Vulnerability to chronic hemoglobin toxicity.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026

Same author

Diagnostic Modalities and Nodal Staging in High-Risk Cutaneous Squamous Cell Carcinoma.

JAMA dermatology·2026

Search research articles

Related Experiment Video

Updated: May 25, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Localized xanthomas associated with primary lymphedema.

Jorge Romaní¹, Jesús Luelmo, Amparo Sáez

¹Department of Dermatology, Hospital Parc Taulí, Sabadell, Barcelona, Spain. xurxoromani@hotmail.com

Pediatric Dermatology

|January 20, 2012

Summary

Verruciform xanthoma, a rare skin condition, occurred in a child with chronic lymphedema. Despite extensive skin lesions on the foot, laboratory tests revealed normal blood lipid levels.

More Related Videos

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

Related Experiment Videos

Last Updated: May 25, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

Area of Science:

Dermatology
Pediatric Medicine
Vascular Medicine

Background:

Cutaneous xanthomas are uncommon in patients with chronic lymphedema.
Lymphedema praecox is a primary condition affecting lymphatic drainage.

Observation:

A 10-year-old boy with primary lymphedema of the left lower extremity presented with verruciform xanthoma.
The xanthoma lesions were located on the left foot and toes.
The patient's medical history included chronic swelling since childhood.

Findings:

Histopathological examination confirmed the diagnosis of verruciform xanthoma.
Laboratory investigations, including a comprehensive lipid profile, revealed no abnormalities.
This suggests a non-lipid-related etiology for the xanthoma in this specific case.

Implications:

This case expands the known spectrum of cutaneous complications associated with chronic lymphedema in pediatric patients.
It underscores the importance of considering rare dermatological conditions even with normal systemic metabolic markers.
Further research may be needed to elucidate the pathogenesis of xanthomas in the context of lymphatic dysfunction.