Related Experiment Video
Updated: May 25, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
Published on: January 7, 2019
Aberrant expression of the apoptosis-related proteins BAK and MCL1 in T cells in multiple sclerosis
Ilana Mandel1, Tamar Paperna, Ariel Miller
1Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Carmel Medical Center, Haifa, Israel.
Abstract:
Pathogenic T cells of multiple sclerosis (MS) patients have been suggested to be endowed with an increased resistance to apoptosis, contributing to their increased survival. We report herein increased levels of the anti-apoptotic MCL1 protein and its half-life in activated lymphocytes of MS patients, which were not associated with differences in MCL1 RNA levels or with alterations in the expression levels of the known E3 ligases of MCL1-β-TrCP and HUWE1. Concomitantly, the expression levels of the pro-apoptotic protein BAK were decreased in MS patients at relapse. These findings suggest the dysregulation of the apoptosis-related proteins MCL1 and BAK in MS.
Related Concept Videos
The Intrinsic Apoptotic Pathway
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
The Extrinsic Apoptotic Pathway
Abnormal Proliferation
Caspases
Multiple Sclerosis l: Introduction

