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Related Concept Videos

Biofilms01:29

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Oral Biofilm Formation on Different Materials for Dental Implants
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Published on: June 24, 2018

Balancing osteoblast functions and bacterial adhesion on functionalized titanium surfaces.

Koon Gee Neoh1, Xuefeng Hu, Dong Zheng

  • 1Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 117576, Singapore. chenkg@nus.edu.sg

Biomaterials
|January 20, 2012
PubMed
Summary

Titanium implants face challenges like poor bone integration and infection. Tailoring implant surfaces to repel bacteria while promoting bone cell growth is key to improving success rates for orthopedic and dental applications.

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Dental Implantology

Background:

  • Titanium and its alloys are widely used for orthopedic and dental implants due to high success rates.
  • Complications include poor bone tissue integration and implant-centered infections.
  • Implant surface interactions with proteins, bacteria, and cells critically influence outcomes.

Purpose of the Study:

  • To explore strategies for modifying implant surfaces to enhance osseointegration and prevent infection.
  • To leverage differential responses of bacteria and osteoblasts to surface properties.
  • To address limitations in achieving ideal implant surface characteristics.

Main Methods:

  • Review of strategies for tailoring implant surfaces.
  • Exploitation of differences in bacterial and osteoblast responses to proteins and surface structures.
  • Discussion of current limitations and future research directions.

Main Results:

  • Surface modification offers a promising avenue to improve implant performance.
  • Tailoring surfaces can simultaneously inhibit bacterial colonization and promote osteoblast functions.
  • Significant challenges remain in developing universally effective implant surface strategies.

Conclusions:

  • Optimizing implant surfaces is crucial for overcoming major complications in orthopedic and dental applications.
  • Further advancements require integrated development of surface modification techniques and a deeper understanding of interfacial biological events.
  • The quest for an ideal implant surface necessitates continued research into biomaterial-surface-cell interactions.