Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Smooth Endoplasmic Reticulum

Smooth Endoplasmic Reticulum

Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Verrucous Variant of Bowen Disease.

The American Journal of dermatopathology·2026

Same author

Pseudolymphomatous Granuloma Annulare Rich in B Lymphocytes.

Dermatopathology (Basel, Switzerland)·2026

Same author

Tumors With GNAQ Mutations: A Review With a Focus on Possible Shared Neural Crest Origins.

The American Journal of dermatopathology·2025

Same author

Immunohistochemical Evaluation of the Quantity of Plasma Cells and Their Distribution Pattern in Zoon's Balanitis.

The American Journal of dermatopathology·2025

Same author

Concepts in Cutaneous Vasculitis.

The American Journal of dermatopathology·2025

Same author

PIK3CA Mutation in FAVA of Adults With Unusual Anatomical Localization.

The American Journal of dermatopathology·2025

Search research articles

Related Experiment Video

Updated: May 25, 2026

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

Cutaneous amyloidosis: a concept review.

Angel Fernandez-Flores¹

¹Department of Pathology, Hospital El Bierzo, Ponferrada, Spain. gpyauflowerlion@terra.es

The American Journal of Dermatopathology

|January 20, 2012

Summary

This review clarifies complex terminology for amyloidosis, focusing on cutaneous forms. It traces the disease

Area of Science:

Medical terminology
Pathology
Dermatology

Background:

Accurate communication between clinicians and pathologists is vital.
Amyloidosis, described over 150 years ago, has abundant, varied, and complex terminology.
Understanding these terms is essential for diagnosis and treatment.

Purpose of the Study:

To discuss key terms related to amyloidosis.
To emphasize concepts specific to cutaneous amyloidosis.
To provide a historical review of amyloidosis concepts.

Main Methods:

Literature review from Virchow to the present.
Analysis of historical and current concepts of amyloidosis.
Examination of diagnostic techniques for cutaneous amyloidosis.

More Related Videos

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

Related Experiment Videos

Last Updated: May 25, 2026

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Performing and Processing FNA of Anterior Fat Pad for Amyloid

Published on: October 30, 2010

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

Main Results:

The historical evolution of amyloidosis concepts is presented.
Classification of various cutaneous amyloidosis forms is detailed.
Diagnostic methods for amyloidosis are reviewed.

Conclusions:

Clarifying amyloidosis terminology improves clinical communication.
A comprehensive understanding of cutaneous amyloidosis is facilitated.
This review provides a foundational resource for clinicians and pathologists.