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Related Experiment Video

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Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
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Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

p53 codon 72 polymorphism and endometriosis: a meta-analysis.

Shuting Jia1, Lin Xu, Ying Chan

  • 1Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, 650500 Yunnan, China.

Archives of Gynecology and Obstetrics
|January 20, 2012
PubMed
Summary

The p53 Arg72Pro polymorphism is linked to increased endometriosis risk in Asian populations, but not in Caucasians. Further global research is needed to confirm this association for the p53 tumor suppressor gene.

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Last Updated: May 25, 2026

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
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Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Area of Science:

  • Genetics
  • Oncology
  • Reproductive Medicine

Background:

  • The p53 tumor suppressor gene's Arg72Pro polymorphism has been investigated for its association with endometriosis.
  • Existing studies on this link present inconsistent findings, necessitating further analysis.

Purpose of the Study:

  • To conduct a meta-analysis to clarify the association between the p53 Arg72Pro polymorphism and endometriosis risk.
  • To evaluate the pooled effect of the p53 codon 72 polymorphism on endometriosis susceptibility.

Main Methods:

  • A systematic literature search was performed on PubMed to identify relevant studies.
  • Studies with available genotype frequencies for the p53 Arg72Pro polymorphism were included.
  • Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association.

Main Results:

  • Six studies comprising 749 endometriosis cases and 857 controls were analyzed.
  • Overall, variant genotypes (Pro/Pro + Arg/Pro) were not significantly associated with endometriosis risk (OR = 1.552, p = 0.103).
  • Stratified analysis revealed an increased endometriosis risk in Asian subjects with the Pro allele under a dominant model (OR = 2.595, p = 0.049), but no significant association was found in Caucasians (OR = 1.005, p = 0.972). Publication bias was assessed and found to be minimal.

Conclusions:

  • The p53 codon 72 Pro/Pro + Arg/Pro genotypes are associated with an elevated risk of endometriosis in Asian populations.
  • The findings suggest a potential ethnic-specific association between the p53 Arg72Pro polymorphism and endometriosis.
  • Further large-scale, global studies are recommended to validate these findings and confirm the association.