Related Experiment Video
Updated: May 25, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
[Immunotherapy for metastatic prostate cancer: do we really need this?]
1Klinik und Poliklinik für Urologie, Universitätsklinikum Aachen, Pauwelsstraße 30, 52074 Aachen, Deutschland. aheidenreich@ukaachen.de
Der Urologe. Ausg. A
|January 20, 2012
Summary
New immunotherapies and antihormonal drugs are advancing castration-resistant prostate cancer management. Sipuleucel-T and immune checkpoint inhibitors show promise, especially for select patients.
Area of Science:
- Oncology
- Immunology
Context:
- Castration-resistant prostate cancer (CRPC) management is evolving.
- Chemotherapy (docetaxel) remains standard for high-burden disease.
- Novel therapies are emerging, including immunotherapy and antihormonal agents.
Purpose:
- To critically review current immune therapy options for CRPC.
- To discuss the role of Sipuleucel-T, ipilimumab, and tasquinimod.
Summary:
- Sipuleucel-T may improve survival in pre-docetaxel CRPC patients.
- Immunotherapy candidates often have minimal tumor burden and favorable prognostic factors.
- Immune checkpoint inhibitors like ipilimumab and tasquinimod show clinical potential.
Impact:
- Highlights the shift towards targeted immunotherapies in CRPC.
- Provides insights into patient selection for immune-based treatments.
- Informs clinical decision-making for advanced prostate cancer management.
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