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Updated: May 25, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Diabetic Cardiovascular Disease Predicts Chronic Kidney Disease Awareness in the Kidney Early Evaluation Program
Insights
Chronic kidney disease (CKD) awareness is low, but cardiovascular disease (CVD) in diabetic patients may increase it. This screening program found CVD presence improved CKD awareness among those with diabetes.
Area of Science:
- Nephrology
- Cardiology
- Public Health
Background:
- Chronic kidney disease (CKD) awareness is generally low.
- Diabetes significantly increases cardiovascular disease (CVD) morbidity, particularly in CKD patients.
- Previous research did not support healthcare delivery or insurance status improving CKD awareness in diabetic populations.
Purpose of the Study:
- To test the hypothesis that a prevalent comorbidity like CVD in diabetic patients predicts CKD awareness.
- To assess the relationship between CVD and CKD awareness in a large screening program.
Main Methods:
- Utilized data from the National Kidney Foundation-Kidney Early Evaluation Program (KEEP).
- Analyzed 77,077 participants, identifying CKD in 20,200 and diabetes in 23,082.
- Compared CVD prevalence and CKD awareness between diabetic and non-diabetic groups, and across CKD stages.
Main Results:
- CVD prevalence was higher in participants with diabetes (39.5%) than without (22.0%).
- CKD awareness was significantly higher in diabetic patients with CVD (8.2%) compared to those without diabetes (2.2%).
- Congestive heart failure was a stronger predictor of awareness in diabetic patients with CVD than myocardial infarction or stroke.
Conclusions:
- CKD awareness remains low overall.
- The presence of CVD in patients with diabetes is associated with increased CKD awareness within a targeted screening program.
- Findings highlight the potential role of comorbid conditions in driving health awareness for chronic diseases.
Aims:
Lack of chronic kidney disease (CKD) awareness is common. Recent data suggest that the presence of concurrent diabetes may heighten CKD awareness, but current data have not supported the hypothesis that healthcare delivery or insurance status improves awareness in the diabetic population. Diabetes is associated with high cardiovascular disease (CVD) morbidity, especially in patients with CKD. We hypothesized that a highly prevalent co-morbid condition such as CVD in patients with diabetes would predict CKD awareness.
Methods:
We utilized data from theNational Kidney Foundation-Kidney Early Evaluation Program (KEEPTM), a large screening program designed to identify high-risk individuals for CKD and promote awareness.
Results:
Among 77,077 participants, CKD was identified in 20,200 and diabetes in 23,082. Prevalence of CVD was higher in participants with than without diabetes (39.5 vs. 22.0%) and in stage 3-5 compared to stage 1-2 CKD (43.3 vs. 34.4%). Patients with diabetes and CVD had a higher level of awareness than those without diabetes (8.2 vs. 2.2%). Among patients with diabetes and CVD, the presence of congestive heart failure was a better predictor of awareness [odds ratio (OR) 1.84; 95% confidence interval (CI) 1.40-2.43] than endpoints such as myocardial infarction or stroke [OR 1.35 (95% CI 1.04-1.73) and OR 1.34 (95% CI 1.04-1.72), respectively].
Conclusions:
While prevalence of CKD awareness remained low, our data suggest that in patients with diabetes the presence of CVD was associated with increased awareness in a targeted screening program for CKD awareness.
Related Concept Videos
Diabetic Nephropathy
Chronic Kidney Disease I: Introduction
Chronic Kidney Disease III: Interprofessional Care
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease IV: Nursing Management
Acute Kidney Injury IV: Diagnostic Studies and Prevention
