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Cognitive function and decline in obesity.

Kelly Stanek Sellbom1, John Gunstad

  • 1Department of Psychology, University of Alabama, Tuscaloosa, AL 35487-0348, USA. kmstanek@as.ua.edu

Journal of Alzheimer'S Disease : JAD
|January 20, 2012
PubMed
Summary
This summary is machine-generated.

Obesity impacts brain function and cognition, leading to cognitive deficits. This review synthesizes research on these obesity-related brain changes and suggests potential reversibility with weight loss.

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Area of Science:

  • Neuroscience
  • Public Health
  • Psychology

Background:

  • Obesity presents significant societal and individual health challenges.
  • Neuropsychological effects of obesity have wide-ranging functional implications.
  • Existing research on obesity-related cognitive dysfunction and brain alterations lacks synthesis.

Purpose of the Study:

  • To integrate recent literature on obesity-related cognitive dysfunction.
  • To review brain alterations associated with obesity.
  • To identify potential mechanisms underlying these neuropathological changes.

Main Methods:

  • Systematic literature review of recent studies.
  • Synthesis of findings on cognitive patterns.
  • Analysis of neuroimaging and other relevant data.

Main Results:

  • Identified specific patterns of cognitive dysfunction in obesity.
  • Documented alterations in brain structure and function linked to obesity.
  • Proposed potential biological and behavioral mechanisms driving these changes.

Conclusions:

  • Obesity is associated with significant cognitive impairments and brain alterations.
  • A preliminary model for obesity-related cognitive dysfunction is presented.
  • Future research should explore the reversibility of these changes with weight loss interventions.