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Updated: May 25, 2026
Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice
Published on: June 11, 2020
Periodic eyelid opening associated with burst-suppression electroencephalography due to hypoxic ischemic injury
Joseph M Ferrara1, David J Houghton, Satish Rao
1Division of Neurology, Virginia Tech Carilion School of Medicine and Research Institute, 2 Riverside Cir, Roanoke, VA 24016, USA. ferrara.jay@gmail.com
Background:
We report four patients who developed periodic eyelid opening following hypoxic ischemic injury. This manuscript reviews the clinical course of our patients as well as previously published cases and discusses the neuroanatomical basis of eyelid opening.
Methods:
Data were collected from the patients' electronic medical record and digital electroencephalography recordings.
Results:
In all patients, periodic eyelid opening was associated with a burst-suppression pattern on electroencephalography (EEG). Rapid eyelid opening appeared with the onset of bursts, while slow eyelid closure coincided with periods of suppression. Progressive rostrocaudal deterioration in brainstem function ensued, in each case culminating in brain death.
Conclusions:
Our experience and prior reports suggest that periodic eyelid opening following cardiac arrest is associated with a burst-suppression pattern on EEG. Since burst-suppression is highly (though not invariably) predictive of a poor outcome in this patient population, intensivists should be familiar with this neurological sign. Prospective studies are needed to define the neurophysiology of this phenomena and clarify its clinical significance.
