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Related Concept Videos

Hand hygiene01:23

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

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Related Experiment Video

Updated: May 25, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Interventions for impetigo.

Sander Koning1, Renske van der Sande, Arianne P Verhagen

  • 1Department of General Practice, ErasmusMedical Center, Rotterdam, Netherlands

The Cochrane Database of Systematic Reviews
|January 20, 2012
PubMed
Summary
This summary is machine-generated.

Topical antibiotics like mupirocin and fusidic acid are effective for impetigo, showing better cure rates than placebo and similar efficacy to each other. Oral antibiotics like penicillin were less effective, and disinfectants lacked evidence of benefit.

Related Experiment Videos

Last Updated: May 25, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Impetigo is a common superficial bacterial skin infection in children with varied treatment guidelines.
  • Current treatment options include oral and topical antibiotics, and disinfectants.
  • This review is an update of the 2003 version, assessing current evidence on impetigo treatments.

Purpose of the Study:

  • To evaluate the effectiveness of various treatments for impetigo.
  • Included interventions range from pharmacological agents to non-pharmacological approaches and natural resolution.
  • Assessed treatments for non-bullous, bullous, primary, and secondary impetigo.

Main Methods:

  • Updated systematic search of multiple databases (Cochrane, MEDLINE, EMBASE, LILACS) up to July 2010.
  • Included randomized controlled trials (RCTs) comparing different impetigo treatments.
  • Data collection and quality assessment performed by two independent authors.

Main Results:

  • 68 RCTs with 5578 participants evaluated 50 treatments.
  • Topical antibiotics demonstrated higher cure rates than placebo (RR 2.24).
  • Mupirocin and fusidic acid showed similar efficacy; topical antibiotics were superior to disinfectants (RR 1.15).
  • Oral erythromycin was more effective than penicillin (RR 1.29) and cloxacillin (RR 1.59).
  • Side-effects were more common with oral antibiotics, primarily gastrointestinal.
  • Growing antibiotic resistance is noted, with no reported resistance to retapamulin.

Conclusions:

  • Topical mupirocin and fusidic acid are effective and comparable treatments for impetigo.
  • Oral antibiotics may be less effective than topical options, with penicillin showing inferior efficacy.
  • Evidence does not support the use of disinfectants for impetigo management.
  • Further research is needed for extensive impetigo cases to clarify optimal treatment strategies.