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Updated: May 25, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Interventions for preventing weight gain after smoking cessation.

Amanda C Farley¹, Peter Hajek, Deborah Lycett

¹Primary Care Clinical Sciences, University of Birmingham, Birmingham, UK.

The Cochrane Database of Systematic Reviews

|January 20, 2012

Summary

Weight gain after quitting smoking is common. While some short-term pharmacotherapies can limit weight gain, long-term effectiveness is uncertain, and personalized support shows promise but needs more data.

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Area of Science:

Addiction research
Behavioral science
Pharmacology

Background:

Weight gain is a common consequence of smoking cessation.
Interventions exist to mitigate post-cessation weight gain (PCWG).
The efficacy of these interventions on weight and cessation rates requires systematic review.

Purpose of the Study:

To review interventions targeting PCWG for their effects on weight and smoking cessation.
To assess interventions aiding smoking cessation that may also influence weight.

Main Methods:

Systematic review of Cochrane reviews and specialized registers.
Inclusion of trials reporting weight and/or smoking cessation data.
Meta-analysis of weight change and smoking abstinence rates.

Main Results:

Pharmacotherapies like dexfenfluramine, phenylpropanolamine, and naltrexone showed short-term weight reduction but not long-term.
Personalized weight management support and very low-calorie diets (VLCDs) showed potential but require more data.
Exercise interventions reduced weight long-term, not short-term.
Bupropion, fluoxetine, nicotine replacement therapy (NRT), and varenicline reduced PCWG during treatment, with limited long-term maintenance.

Conclusions:

Short-term pharmacotherapy benefits for PCWG are limited by long-term efficacy data and side effects.
Weight management education alone is ineffective and may reduce abstinence.
Personalized support and exercise show promise but need further research.
Current evidence is insufficient for definitive clinical recommendations on preventing PCWG.