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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

External counterpulsation for acute ischaemic stroke.

Sen Lin¹, Ming Liu, Bo Wu

¹Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

The Cochrane Database of Systematic Reviews

|January 20, 2012

Summary

External counterpulsation (ECP) may improve neurological function in acute ischaemic stroke patients. However, current evidence is limited due to poor study quality, necessitating further research.

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Area of Science:

Neurology
Cardiovascular Medicine
Rehabilitation

Background:

External counterpulsation (ECP) is a non-invasive therapy that augments diastolic arterial pressure, potentially improving cerebral blood flow.
ECP has been investigated as a therapeutic option for patients experiencing acute ischaemic stroke.

Purpose of the Study:

To systematically evaluate the efficacy and safety of external counterpulsation (ECP) in the treatment of acute ischaemic stroke.

Main Methods:

A comprehensive literature search was conducted across multiple databases (e.g., MEDLINE, EMBASE, CENTRAL) up to June 2011.
Included were randomized controlled trials (RCTs) comparing ECP with sham treatment or no treatment in acute ischaemic stroke patients.
Two independent reviewers assessed trial quality, extracted data, and checked for adverse events.

Main Results:

Two RCTs with a total of 160 patients were included in the review.
ECP demonstrated a significant increase in the number of participants with improved neurological impairment (Risk Ratio: 1.75, 95% CI: 1.37 to 2.23).
Data on mortality or long-term dependency were not reported, and only one trial reported no adverse events.

Conclusions:

The existing studies on ECP for acute ischaemic stroke suffer from poor methodological quality.
Reliable conclusions regarding the efficacy and safety of ECP cannot be drawn from the current evidence.
High-quality, large-scale randomized controlled trials are essential to determine the true benefit of ECP in this patient population.