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Updated: May 25, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
1-Benzoyl-3-(2,4,5-trichloro-phen-yl)thio-urea
Abstract:
The benzene and phenyl rings in the title compound, C(14)H(9)Cl(3)N(2)OS, form a dihedral angle of 40.98 (6)°. The mol-ecule exists in the thione form with typical thio-urea C-S [1.666 (2) Å] and C-O [1.227 (3) Å] bond lengths as well as shortened C-N bonds [1.345 (3) and 1.386 (2) Å]. An intra-molecular N-H⋯O hydrogen bond stabilizes the mol-ecular conformation. In the crystal, pairs of N-H⋯S hydrogen bonds link the mol-ecules into centrosymmetric dimers.
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For disubstituted benzene derivatives, with two groups attached to the benzene ring, three constitutional isomers are possible. For example, consider dimethyl benzene, often called xylene, where the second methyl group can be substituted at the second, third, or fourth carbon. The relative position of the substituents is represented by prefixes ortho, meta, or...

