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Updated: May 25, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
(2-Anilino-4-methyl-thia-zol-5-yl)(4-chloro-phen-yl)methanone
Jing-Jing Liu1, Ren-Lin Zheng, Sheng-Yong Yang
1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People's Republic of China.
Abstract:
The title compound, C(17)H(13)ClN(2)OS, crystallizes with three independent mol-ecules (A, B and C) in the asymmetric unit which differ slightly in their conformations. In mol-ecule A, the thiazole ring makes dihedral angles of 27.44 (14) and 66.05 (6)° with the phenyl and chloro-benzene rings. In mol-ecule B, the respective angles are 29.09 (10) and 47.63 (9)°, while values of 25.67 (11) and 51.01 (7)° are observed in mol-ecule C. In the crystal, N-H⋯N and N-H⋯O hydrogen bonds generate a three-dimensional network structure.
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