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Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
2,9,10-Trimeth-oxy-dibenzo[b,d]oxepin-7(6H)-one
Yan-Jun Hou1, Shu-Lin Song, Wen-Yi Chu
1College of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, People's Republic of China.
Acta Crystallographica. Section E, Structure Reports Online
|January 20, 2012
Summary
A novel compound, C(17)H(16)O(5), was synthesized via cyclization. Its crystal structure reveals a specific dihedral angle between benzene rings and no hydrogen bonds.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Biphenyl derivatives are important in medicinal chemistry and materials science.
- Understanding the structural properties of novel organic compounds is crucial for their application.
Purpose of the Study:
- To synthesize and characterize a novel biphenyl derivative, C(17)H(16)O(5).
- To elucidate the crystal structure of the title compound.
Main Methods:
- Cyclization reaction of 2-(3',4',5-trimethoxy-biphenyl-2-yl-oxy)acetyl chloride.
- Single-crystal X-ray diffraction analysis.
Main Results:
- Successful synthesis of the title compound C(17)H(16)O(5).
- The crystal structure was determined, showing a dihedral angle of 34.55(5)° between the two benzene rings.
- Absence of intermolecular hydrogen bonds in the crystal lattice.
Conclusions:
- The cyclization reaction provides a viable route to C(17)H(16)O(5).
- The determined dihedral angle offers insights into the conformational preferences of this biphenyl system.
- The lack of hydrogen bonding influences the compound's solid-state properties.
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