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Updated: May 25, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
3-Cyclo-propyl-1-(4-methyl-phenyl-sulfon-yl)piperidine-3,5-diol
1College of Chemistry and Engineering, Yunnan Normal University, Kunming, People's Republic of China.
Abstract:
In the title compound, C(15)H(21)NO(4)S, both hy-droxy groups on the piperidine ring are located in axial positions, whereas the tosyl group and the cyclo-propane ring are in equatorial positions. An intra-molecular O-H⋯O hydrogen bond occurs. In the crystal, mol-ecules form inversion dimers via pairs of O-H⋯O hydrogen bonds, generating cyclic R(4) (4)(8) motifs, as noted previously in related diols.
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