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Updated: Oct 3, 2026

Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
Modification by SQ 14225 of blood pressure and adrenal catecholamine response to hemorrhage
Abstract:
SQ 14225 infusion to cats exposed to hemorrhage suppressed adrenomedullary catecholamine release. The immediate compensatory blood pressure response was unaffected, while the later compensatory response was of a higher magnitude in intact cats that in SQ 14225-treated animals. Adrenal gland blood flow was better preserved in SQ 14225-treated hemorrhaged cats than in cats exposed to hemorrhage only. These data emphasize the role of angiotensin II in adrenal catecholamine and blood pressure responses to hemorrhage.
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