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Related Experiment Videos

Decrease of cyclic GMP in cerebellar cortex by intrastriatal (--)-sulpiride.

M G Corda, M Casu, G Biggio

    European Journal of Pharmacology
    |May 1, 1979
    PubMed
    Summary
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    (-)--Sulpiride administration reduced cerebellar cyclic guanosine monophosphate (cGMP) levels in a dose-dependent manner. This suggests that the drug

    Area of Science:

    • Neuropharmacology
    • Neurochemistry

    Background:

    • Cyclic guanosine monophosphate (cGMP) plays a role in cerebellar function.
    • Dopamine receptors are implicated in various neurological processes.

    Purpose of the Study:

    • To investigate the effect of (-)--sulpiride on cerebellar cGMP levels.
    • To explore the mechanism of action of (-)--sulpiride on cerebellar cGMP.

    Main Methods:

    • Intraperitoneal administration of (-)--sulpiride and (+)-sulpiride in rodents.
    • Measurement of cGMP content in cerebellar cortex.

    Main Results:

    • (-)--Sulpiride administration resulted in a dose-related decrease in cerebellar cGMP.
    • The effect was observed after systemic administration, not direct cerebellar injection.

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    Conclusions:

    • (-)--Sulpiride modulates cerebellar cGMP levels.
    • This modulation is likely mediated through an action on striatal dopamine receptors.