Related Experiment Video
Updated: May 25, 2026

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
Published on: August 16, 2018
Amyrisins A-C, O-prenylated flavonoids from Amyris madrensis
Jiangnan Peng1, Rachel M Hartley, Gary A Fest
1Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Abstract:
Three new O-prenylated flavonoids, amyrisins A-C (1-3), were isolated from the leaves and twigs of Amyris madrensis, along with the known compound polygamain (4). The structures of 1-3 were elucidated on the basis of the analysis of spectroscopic data interpretation. Amyrisins B (2) and C (3) showed moderate cytotoxicity against PC-3 and DU 145 prostate cancer cells with IC(50) values of 17.5 and 23 microM, respectively, while amyrisin A (1) did not show any cytotoxicity at the highest concentration tested, 50 microM. Polygamain (4) exhibited potent antiproliferative and microtubule-depolymerizing activities.
Related Concept Videos
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Preparation of Amines: Reduction of Oximes and Nitro Compounds
Though catalytic hydrogenation can reduce nitrobenzenes, the reduction is nonselective in the presence of other functional groups. For instance, if nitrobenzene contains an aldehyde group,...
Preparation of Amines: Reductive Amination of Aldehydes and Ketones
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary amide...
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview

