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Intravenous lidocaine has no impact on rocuronium-induced neuromuscular block. Randomised study
C Czarnetzki1, C Lysakowski, N Elia
1Division of Anaesthesiology, Geneva University Hospitals, Geneva, Switzerland. christoph.czarnetzki@hcuge.ch
Acta Anaesthesiologica Scandinavica
|January 21, 2012
Summary
Intravenous lidocaine infusion does not alter the duration of rocuronium-induced neuromuscular blockade in surgical patients. This study found no significant differences in onset, recovery, or clinical duration of the block with lidocaine compared to saline.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Intravenous lidocaine use is rising in surgical settings.
- Lidocaine possesses neuromuscular blocking properties, necessitating investigation into its interaction with muscle relaxants.
Purpose of the Study:
- To evaluate the effect of continuous intravenous lidocaine infusion on the time course of neuromuscular blockade induced by rocuronium.
Main Methods:
- A randomized controlled trial involving 52 adult surgical patients.
- Participants received either intravenous lidocaine or saline infusion throughout surgery.
- Neuromuscular transmission was monitored using acceleromyography (train-of-four).
Main Results:
- No significant differences were observed in the onset time of neuromuscular blockade.
- Total recovery time, clinical duration, and recovery index showed no statistically significant variations between the lidocaine and saline groups.
- Specific metrics like onset time (113.9s vs 119.5s) and total recovery time (58.1min vs 54.3min) were comparable.
Conclusions:
- Continuous intravenous lidocaine infusion does not impact the time course of neuromuscular blockade induced by a standard intubation dose of rocuronium.
- The findings suggest that lidocaine does not potentiate or antagonize the effects of rocuronium on neuromuscular transmission.
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