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Related Experiment Videos

Urinary incontinence: classification and pharmacological therapy.

D R Staskin1, A J Wein, K E Andersson

  • 1Division of Urology, Harvard University School of Medicine, Beth Israel Hospital, Boston, MA 02215.

Ciba Foundation Symposium
|January 1, 1990
PubMed
Summary

This review examines pharmacological treatments for urinary incontinence and voiding dysfunction. It highlights challenges in interpreting clinical studies and proposes a functional classification for developing more effective uropharmacological therapies.

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Area of Science:

  • Pharmacology
  • Urology
  • Drug Development

Background:

  • Pharmacological therapies significantly impact urinary incontinence and voiding dysfunction management.
  • Clinical studies on drug efficacy for voiding dysfunction are often difficult to interpret, contradictory, and lack bias, adequate subjects, or valid statistical design.
  • Interpreting in vitro pharmacological studies is challenging due to diverse experimental models and the need to extrapolate to in vivo activity.

Purpose of the Study:

  • To review the current state of pharmacological therapy for urinary incontinence and voiding dysfunction.
  • To address the limitations and interpretability issues in existing clinical and laboratory studies.
  • To promote discussion on applying uropharmacological investigation for developing novel, effective drug therapies.

Main Methods:

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  • Utilizes a functional scheme to classify pharmacological agents based on their effects on urinary storage and emptying.
  • Critically evaluates the quality and validity of existing clinical laboratory studies.
  • Reviews in vitro pharmacological studies and their extrapolation to in vivo activity.

Main Results:

  • Identifies significant challenges in interpreting the efficacy of commonly prescribed drugs for voiding dysfunction due to study limitations.
  • Highlights the value of laboratory research while noting difficulties in extrapolating in vitro findings.
  • Proposes a functional classification system as a framework for future drug development.

Conclusions:

  • There is a need for improved rigor and standardization in clinical trials for uropharmacological agents.
  • A functional classification approach can aid in the systematic development of more efficacious treatments.
  • Further research applying uropharmacological principles is essential for advancing drug therapy in urology.