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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

ERK5 and its role in tumour development.

Pamela A Lochhead¹, Rebecca Gilley, Simon J Cook

¹Laboratory of Signalling and Cell Fate, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK. pamela.lochhead@babraham.ac.uk

Biochemical Society Transactions

|January 21, 2012

Summary

The MEK5/ERK5 pathway, a key part of mitogen-activated protein kinase (MAPK) signaling, is increasingly implicated in cancer. Further research is needed to understand its role in tumor growth, invasion, and migration.

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Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

Area of Science:

Cell Biology
Molecular Biology
Oncology

Background:

The MEK5/ERK5 pathway is the least understood mitogen-activated protein kinase (MAPK) signaling module.
This pathway is increasingly recognized for its potential role in cancer pathology.

Purpose of the Study:

To review the role of the MEK5/ERK5 pathway in cancer using the 'hallmarks of cancer' framework.
To examine how the MEK5/ERK5 pathway is deregulated in the context of cancer.

Main Methods:

Literature review focusing on the MEK5/ERK5 pathway and cancer hallmarks.
Analysis of existing data on oncogene stimulation and genetic alterations affecting the pathway.

Main Results:

ERK5 plays a role in endothelial cell survival and tubular morphogenesis during tumor neovascularization.
ERK5 is emerging as a regulator of tumor cell invasion and migration.
MEK5/ERK5 pathway activity is stimulated by oncogenes and its protein levels are affected by chromosomal amplification (17p11) and microRNA down-regulation (miR-143, miR-145).

Conclusions:

The MEK5/ERK5 pathway is deregulated in cancer through various mechanisms.
ERK5's multifaceted roles in tumor growth, vascularization, and metastasis warrant further investigation.
Understanding the MEK5/ERK5 pathway is crucial for developing novel cancer therapies.