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Protein kinase D in the hypertrophy pathway

Yuan Yan Sin1, George S Baillie

  • 1Molecular Pharmacology Group, Institute of Cardiovascular and Medical Science, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK. y.sin.1@research.gla.ac.uk

Biochemical Society Transactions
|January 21, 2012
PubMed

Insights

Protein kinase D (PKD) plays a key role in heart hypertrophy by regulating histone deacetylase 5 (HDAC5) translocation. Understanding this pathway offers potential new treatments for heart failure.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biochemistry

Background:

  • Chronic neurohormonal stimulation adversely affects cardiac structure and function, leading to heart failure.
  • Phosphorylation of class II histone deacetylase 5 (HDAC5) is crucial for cardiac gene reprogramming and hypertrophy.
  • Protein kinase D (PKD) is implicated in the regulation of HDAC5 translocation.

Purpose of the Study:

  • To review recent insights into the role of PKD in cardiac hypertrophic signaling pathways.
  • To explore the potential of PKD-mediated mechanisms as therapeutic targets for heart failure.

Main Methods:

  • This review summarizes existing experimental findings and recent observations.
  • Focuses on the regulatory properties of PKD in HDAC5 phosphorylation and translocation within cardiac cells.

Main Results:

  • PKD-mediated regulation of HDAC5 is a significant event in cardiac hypertrophy.
  • Recent observations suggest PKD's role in myocardial regulation may offer therapeutic potential.

Conclusions:

  • PKD signaling is a critical component of the hypertrophic response in the heart.
  • Targeting PKD-mediated pathways presents a promising avenue for developing novel heart failure therapies.

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