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Updated: May 25, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Synthesis, spectral studies and solvatochromic analysis of novel imidazole derivatives
Jayaraman Jayabharathi1, Venugopal Thanikachalam, Natesan Srinivasan
1Department of Chemistry, Annamalai University, Annamalainagar, Tamilnadu 608 002, India. jtchalam2005@yahoo.co.in
Abstract:
Bioactive imidazole derivatives were synthesized and characterized by spectral techniques. The photophysical properties of imidazole derivatives were studied in several solvents. The observed spectral shift is attributed to a loss of planarity in the excited state provided by the non-co-planarity of the aryl rings attached to C(2) and N(1) atoms of the imidazole ring. The observed solvatochromic shifts were analyzed in detail by Kamlet-Taft and Catalan parameters. The interaction between bioactive imidazole derivative and bovine serum albumin (BSA) was also investigated.
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