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Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
The nutrition of preterm infants
Mario De Curtis1, Jacques Rigo
1Dipartimento di Pediatria e Neuropsichiatria Infantile, Università di Roma La Sapienza, Rome, Italy.
Insights
Optimizing nutrition for very low birthweight (VLBW) infants is crucial. Aggressive nutritional strategies, including high amino acid parenteral nutrition and fortified human milk, support growth and prevent extrauterine growth restriction.
Area of Science:
- Neonatalogy
- Pediatric Nutrition
- Intensive Care Medicine
Background:
- Very low birthweight (VLBW) infants often suffer from inadequate nutrient intake, leading to extrauterine growth restriction.
- Traditional nutritional support may not meet the high demands for growth and development in VLBW infants.
- Minimizing nutrient interruption at birth is essential for optimal neonatal outcomes.
Purpose of the Study:
- To review and advocate for aggressive nutritional strategies in VLBW infants.
- To highlight the importance of early and high amino acid supply.
- To discuss the role of parenteral and enteral nutrition, including human milk fortification and specialized formulas.
Main Methods:
- Review of current literature on neonatal nutrition for VLBW infants.
- Emphasis on parenteral nutrition when enteral feeding is not feasible.
- Discussion of human milk fortification and alternative preterm formulas.
Main Results:
- High amino acid supply from day one can prevent catabolism and promote anabolism.
- Fortified human milk is recommended to meet nutrient needs and support bone mineralization.
- Specialized cow's milk-based formulas are necessary when human milk is insufficient.
Conclusions:
- Aggressive nutritional management, including early high amino acid intake, is vital for VLBW infants.
- Optimizing nutrition through fortified human milk or preterm formulas supports growth and development.
- Parenteral nutrition plays a critical role when enteral feeding is compromised.
Abstract:
Although great efforts have been made to improve neonatal nutrition in very low birthweight (VLBW) infants, many do not receive adequate nutrient intake and thus develop extrauterine growth restriction. In order to minimize the interruption of nutrients that occurs at birth, an "aggressive" nutritional approach has been proposed. Parenteral nutrition, which allows the infant's requirements for growth and development to be met, is indicated in infants for whom feeding via the enteral route is impossible, inadequate, or hazardous. In the last few years, great attention has been given to high amino acid supply in VLBW infants from the first day of life in order to avoid catabolism, establish anabolism, achieve in utero protein accretion rates, and promote linear growth. Whenever possible, enteral feeding should commence with human milk, which is the preferred feeding method for all infants, including those born preterm. In order to meet the unique nutritional requirements of VLBW infants and preserve the singular benefit of breastfeeding, human milk should be fortified to allow adequate growth and bone mineralization. When feeding of preterm infants with human milk is impossible or extremely limited, cow-milk-based formulas for preterm infants must be used.
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