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Association between adiponectin gene polymorphisms and coronary artery disease across different populations
1Department of Sports Physiology, Hunan University of Science and Technology, Xiangtan 411201, China. liangzhou0731@163.com
Objective:
Many studies have suggested that adiponectin gene might be involved in the development of coronary artery disease (CAD). However, the results have been inconsistent. In this study, the authors performed a meta-analysis to assess the associations of +45T/G, +276G/T and -11377C/G polymorphisms in adiponectin gene with CAD susceptibility.
Methods:
Published literature from PubMed and EMBASE databases were searched. Pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated using fixed- or random-effects model.
Results:
Sixteen studies (4394 cases / 8187 controls) for +45T/G polymorphism, fifteen studies (3569 cases / 7463 controls) for +276G/T polymorphism, and thirteen studies (3531 cases / 7072 controls) for -11377C/G polymorphism were included in the meta-analysis. The overall results showed that there was a statistically significant association between -11377C/G polymorphism and CAD (G vs. C: OR=1.15, 95%CI 1.07-1.24).Similar results were observed among European (G vs. C: OR=1.11, 95%CI 1.02-1.20) and East Asian populations (G vs. C: OR=1.27, 95%CI 1.11-1.45). However, no significant association was found for +45T/G or +276G/T polymorphism with CAD susceptibility.
Conclusions:
The meta-analysis indicated the significant association of -11377C/G polymorphism, but not +45T/G or +276G/T polymorphism, with CAD susceptibility. However, large-scale studies with the consideration of gene-gene and gene-environment interactions should be conducted to investigate the associations in future.
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