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[Paroxysmal non-hereditary angioedema].

J Steurer1, G Siegenthaler-Zuber, W Siegenthaler

  • 1Departement für Innere Medizin, Universitätsspital Zürich.

Deutsche Medizinische Wochenschrift (1946)
|October 19, 1990
PubMed
Summary
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This study details recurrent hypovolaemic shock caused by increased capillary permeability, a condition known as capillary leak syndrome. The syndrome presents with severe symptoms and has a poor prognosis despite temporary treatment.

Area of Science:

  • Internal Medicine
  • Pathophysiology

Background:

  • Recurrent hypovolaemic shock episodes were observed in two previously healthy individuals.
  • The condition manifested with symptoms including limb edema, thirst, sweating, tachycardia, and orthostatic complaints.

Observation:

  • Severe hemodynamic instability occurred, with marked drops in blood pressure and elevated heart rates.
  • Significant hemoconcentration was noted, indicated by high hematocrit and hemoglobin levels.
  • Temporary improvement was achieved with plasma expanders, but symptoms recurred.

Findings:

  • The underlying cause identified was increased permeability of tissue capillaries.
  • Renal, pulmonary, and cerebral vasculature appeared unaffected.
  • Pharmacological interventions (ketotifen and gingko biloba extract) showed limited long-term efficacy.

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Implications:

  • Capillary leak syndrome is a serious condition with a poor prognosis.
  • Further research is needed to identify effective long-term treatments.
  • Early diagnosis and management are crucial for patients with recurrent hypovolaemic shock.