Related Experiment Video
Updated: May 25, 2026
10:25
Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
Silent new DWI lesions within the first week after stroke
Christian H Nolte1, Fredrik N Albach, Peter U Heuschmann
1Department of Neurology, Charité Benjamin Franklin Campus, Berlin, Germany.
Cerebrovascular Diseases (Basel, Switzerland)
|January 21, 2012
Summary
New diffusion-weighted imaging (DWI) lesions after stroke are more common than clinical exams suggest. Factors like carotid stenosis and recanalization predict these new brain lesions.
Area of Science:
- Neurology
- Radiology
- Stroke Medicine
Background:
- Clinical examination is limited in detecting new cerebral lesions post-stroke.
- Diffusion-weighted imaging (DWI) offers higher sensitivity for identifying new brain lesions.
Purpose of the Study:
- To determine the rate of new DWI lesions at two intervals post-stroke.
- To identify predictors associated with these new lesions.
Main Methods:
- 159 acute ischemic stroke patients underwent DWI at 3 time points.
- New lesions were identified by blinded investigators comparing serial DWI scans.
- Logistic regression analyzed predictors of new DWI lesions.
Main Results:
- Clinical recurrence was 2.5%; new DWI lesions occurred in 5.7% (interval 1) and 23.3% (interval 2).
- Early predictors included thrombolysis and multiple lesion patterns.
- Later predictors included carotid stenosis, recanalization, atrial fibrillation, older age, and higher NIHSS.
Conclusions:
- New DWI lesions are frequently detected, exceeding clinical detection rates.
- Thrombolysis linked to very early lesions; carotid stenosis and recanalization linked to later lesions.
More Related Videos
13:18Optimization of the Longa Middle Cerebral Artery Occlusion Method for Complete Reperfusion
Published on: November 22, 2024
09:08Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area
Published on: February 2, 2017
Related Concept Videos
01:26Transient Ischemic Attack l: Introduction
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
01:29Stroke: Introduction and Types
A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...