Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila.

Nature communications·2026
Same author

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth by promoting tracheogenesis.

bioRxiv : the preprint server for biology·2025
Same author

The economic impact of purulent vaginal discharge in dairy herds within a single lactation.

Journal of dairy science·2024
Same author

Evaluating differences in milk production, reproductive performance, and survival associated with vaginal discharge characteristics and fever in postpartum dairy cows.

Journal of dairy science·2024
Same author

OPERA tau neutrino charged current interactions.

Scientific data·2021
Same author

Extracellular acidosis enhances Zika virus infection both in human cells and ex-vivo tissue cultures from female reproductive tract.

Emerging microbes & infections·2021

Related Experiment Video

Updated: May 25, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Leptin, cortisol and distinct concurrent training sequences.

G Rosa1, E Dantas, C Biehl

  • 1Laboratory of Human Kinetics Science of the Federal University of Rio de Janeiro State - LABIMH/UNIRIO - Rio de -Janeiro, Brazil. grfi tness@hotmail.com

International Journal of Sports Medicine
|January 21, 2012
PubMed
Summary

Concurrent training, combining cycling and strength exercises, significantly reduced both leptin and cortisol levels in participants. The order of exercises did not impact these beneficial hormonal changes.

More Related Videos

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models
08:31

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Published on: December 17, 2021

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

Related Experiment Videos

Last Updated: May 25, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models
08:31

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Published on: December 17, 2021

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

Area of Science:

  • Exercise Physiology
  • Endocrinology

Background:

  • Leptin and cortisol are key hormones regulating metabolism and stress.
  • Concurrent training, integrating different exercise types, is popular but its hormonal effects require clarification.

Purpose of the Study:

  • To investigate the impact of different concurrent training sequences on serum leptin and cortisol levels.
  • To determine if the order of cycling and strength training affects hormonal responses.

Main Methods:

  • Ten healthy subjects underwent three conditions: control, concurrent training 1 (cycling then strength), and concurrent training 2 (strength then cycling).
  • Serum leptin and cortisol levels were measured before and after each session.
  • Statistical analysis included Shapiro-Wilk, 2-way ANOVA, and Tukey post-hoc tests.

Main Results:

  • Both concurrent training sequences led to significant reductions in leptin levels (CT1: -16.04%, CT2: -8.54%).
  • Cortisol levels also decreased significantly following both sequences (CT1: -26.32%, CT2: -33.57%).
  • A significant correlation was observed between leptin and cortisol levels, particularly in the control session.

Conclusions:

  • Concurrent training effectively reduces both leptin and cortisol levels.
  • The sequence of exercise (cycling followed by strength, or vice versa) does not alter the overall reduction in these hormones.