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Related Experiment Videos

A widely distributed antigen developmentally regulated in the nervous system.

O Pourquié1, M Coltey, J L Thomas

  • 1Institut d'embryologie cellulaire et moléculaire du CNRS et du Collège de France, Nogent sur Marne.

Development (Cambridge, England)
|August 1, 1990
PubMed
Summary

Researchers discovered a novel glycoprotein, BEN, transiently expressed on developing neurons. This molecule appears on neurons during axon growth and disappears as glial cells proliferate, suggesting a role in neural development and adhesion.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Cell surface glycoproteins play crucial roles in neural development.
  • Understanding transiently expressed molecules is key to deciphering neuronal differentiation and guidance.

Purpose of the Study:

  • To identify and characterize a novel glycoprotein expressed on developing neurons.
  • To investigate the expression pattern and potential function of this glycoprotein in the vertebrate nervous system.

Main Methods:

  • Monoclonal antibody production and characterization.
  • Immunohistochemistry and immunocytochemistry on developing nervous system tissues and cell cultures.
  • Preliminary biochemical analysis of the purified glycoprotein.

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Main Results:

  • Identification of a 95-100 kDa glycoprotein, termed BEN, using a specific monoclonal antibody.
  • BEN is transiently expressed on the cell surface of peripherally projecting neurons, including motor, sensory, sympathetic, parasympathetic, and enteric neurons.
  • BEN expression appears on neuronal cell bodies after cell cycle withdrawal, extends to axons, and is downregulated as glial cells (satellite and Schwann cells) proliferate.

Conclusions:

  • BEN represents a novel, transiently expressed surface glycoprotein in the vertebrate nervous system.
  • Its expression pattern suggests a role in neuronal development, potentially in selective adhesion phenomena like axonal fasciculation.
  • BEN's unique expression profile differentiates it from previously described axonal glycoproteins.