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Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study
Kristian S Frederiksen1, Ellen Garde, Arnold Skimminge
1Memory Disorders Research Group, Department of Neurology, Copenhagen University Hospital, Copenhagen, The Netherlands.
Objective:
To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly.
Methods:
This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects.
Results:
328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01).
Conclusion:
The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.
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