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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

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Updated: May 25, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Asthma and coagulation.

J Daan de Boer¹, Christof J Majoor, Cornelis van 't Veer

¹Academic Medical Center,University of Amsterdam, Center for Experimental and Molecular Medicine, Meibergdreef 9, Amsterdam, The Netherlands. j.d.deboer@amc.uva.nl

|January 21, 2012

Summary

This summary is machine-generated.

Asthma involves airway inflammation and obstruction. New research highlights how blood clotting and fibrinolysis disruptions in the lungs worsen asthma, suggesting new treatment targets.

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Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

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Last Updated: May 25, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Area of Science:

Pulmonary Medicine
Hematology
Immunology

Background:

Asthma is a chronic airway disease with no cure, managed symptomatically.
Recent research reveals the significant role of hemostasis in asthma pathophysiology.
The lungs in asthma patients exhibit a procoagulant state, with impaired anticoagulant and fibrinolytic systems.

Purpose of the Study:

To review the current understanding of hemostasis in asthma.
To explore the link between coagulation, inflammation, and asthma severity.
To identify potential new therapeutic targets for asthma.

Main Methods:

Literature review of studies on asthma and hemostasis.
Analysis of the role of coagulation pathways, fibrinolytic system, and platelets.
Examination of protease-activated receptors in asthma.

Main Results:

Asthma is characterized by a procoagulant state in the bronchoalveolar space.
Impaired local anticoagulant protein C system and fibrinolysis activity are observed.
Protease-activated receptors act as a molecular link between coagulation and allergic inflammation.

Conclusions:

Disturbed hemostatic balance significantly impacts asthma severity and manifestations.
Targeting hemostatic pathways presents a promising avenue for novel asthma treatments.