Failure to demonstrate the effect of glucose on insulin removal by perfused rat liver

The effect of glucose on insulin removal by perfused liver of fed and fasted rats has been studied. The perfusion medium contained glucose at a concentration of 300 mg/dl or no glucose. It has been found that glucose has no effect on insulin removal in either group and that fasting had no effect on this process. It is concluded that blood glucose concentration does no influence insulin removal by the liver.