Related Experiment Video

Updated: May 25, 2026

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

Current pharmacologic approaches for prevention and treatment of bronchopulmonary dysplasia

Kristen Tropea1, Helen Christou

  • 1Division of Newborn Medicine, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA.

International Journal of Pediatrics
|January 21, 2012
PubMed

Insights

Bronchopulmonary dysplasia (BPD), a complication of preterm birth, arises from complex factors like ventilator injury and oxygen exposure. This review examines current and future pharmacological treatments to prevent and manage BPD.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Critical Care Medicine

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant complication following preterm birth.
  • It leads to severe, long-term adverse health outcomes in affected infants.
  • The exact causes of BPD are complex, multifactorial, and not fully understood.

Purpose of the Study:

  • This review aims to discuss current evidence for pharmacological interventions in BPD.
  • It also seeks to identify promising future therapeutic strategies for BPD prevention and management.

Main Methods:

  • The review synthesizes existing research on BPD pathogenesis and treatment.
  • It evaluates current preventive and therapeutic strategies, including ventilator management, oxygen therapy, and nutritional support.
  • Evidence for pharmacological interventions is critically assessed.

Main Results:

  • Current strategies, including lung-protective ventilation and specific interventions, show variable success.
  • Pharmacological and nutritional approaches target different aspects of BPD.
  • These interventions are often used in combination for optimal effect.

Conclusions:

  • A deeper understanding of BPD pathogenesis is crucial for developing novel preventive approaches.
  • Future therapeutic modalities show promise in managing BPD.
  • Rigorous evaluation of new strategies within current clinical practice is essential to confirm efficacy.

Related Concept Videos

Chronic Obstructive Pulmonary Disease-V: Management01:29

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Chronic Obstructive Pulmonary Disease-V: Nursing Management01:30

Chronic Obstructive Pulmonary Disease-V: Nursing Management

Nursing management of Chronic Obstructive Pulmonary Disease (COPD) is crucial for providing thorough care and support to patients. Nurses play an integral role in this process through detailed assessment, careful planning, targeted interventions, and ongoing evaluation. Here's an overview of the critical steps in nursing management for COPD.
Assessment
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)