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Published on: May 21, 2017
Aortic Valve Replacement for Aortic Stenosis and Concomitant Coronary Artery Bypass: Long-term Outcomes and
Won-Chul Cho1, Dong-Gon Yoo, Joon-Bum Kim
1Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Korea.
Insights
Coronary artery bypass grafting (CABG) with aortic valve replacement (AVR) for aortic stenosis shows acceptable surgical outcomes. Key predictors of mortality include patient age, reduced glomerular filtration rate (GFR), and left ventricular (LV) mass.
Area of Science:
- Cardiovascular Surgery
- Cardiac Surgery Outcomes
- Aortic Stenosis Management
Background:
- Aortic stenosis frequently necessitates aortic valve replacement (AVR).
- Coronary artery disease (CAD) often coexists with aortic stenosis.
- Combined AVR and coronary artery bypass grafting (CABG) is a complex surgical procedure.
Purpose of the Study:
- To evaluate surgical results of combined AVR and CABG for aortic stenosis.
- To identify predictors of long-term survival in these patients.
- To assess the safety and efficacy of this combined surgical approach.
Main Methods:
- Retrospective analysis of 183 patients undergoing combined AVR and CABG for aortic stenosis (1990-2009).
- Mean follow-up of 59.8 months with 98.3% follow-up completion.
- Cox regression analysis used to determine mortality predictors.
Main Results:
- Low in-hospital mortality rate of 2.7% (5 patients).
- Long-term survival rates of 91.5% (1 year), 74.8% (5 years), and 59.6% (10 years).
- Significant mortality predictors identified: advanced age, GFR < 60 mL/min, and increased left ventricular (LV) mass.
Conclusions:
- Combined AVR and CABG for aortic stenosis and CAD yields acceptable surgical outcomes.
- Patient age, impaired renal function (GFR < 60 mL/min), and LV mass are critical determinants of long-term survival.
- Risk stratification using these factors can aid in patient management.
Background:
We evaluated the surgical results and predictors of long-term survival in patients who underwent coronary artery bypass grafting (CABG) at the time of an aortic valve replacement (AVR) due to aortic stenosis.
Materials And Methods:
Between January 1990 and December 2009, 183 consecutive patients underwent CABG and concomitant aortic valve replacement for aortic stenosis. The mean follow-up period was 59.8±3.3 months and follow-up was possible in 98.3% of cases. Predictors of mortality were determined by Cox regression analysis.
Results:
There were 5 (2.7%) in-hospital deaths. Follow-up of the in-hospital survivors documented late survival rates of 91.5%, 74.8%, and 59.6% at 1, 5, and 10 postoperative years, respectively. Age (p<0.001), a glomerular filtration rate (GFR) less than 60 mL/min (p=0.006), and left ventricular (LV) mass (p<0.001) were significant predictors of mortality in the multivariate analysis.
Conclusion:
The surgical results and long-term survival of aortic valve replacement with concomitant CABG in patients with aortic stenosis and coronary artery disease were acceptable. Age, a GFR less than 60 mL/min, and LV mass were significant predictors of mortality.
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