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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: May 25, 2026

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique
07:34

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Published on: December 15, 2023

Selective ozone concentrations may reduce the ischemic damage after a stroke.

Maria Frosini1, Antonella Contartese, Iacopo Zanardi

  • 1Dipartimento di Neuroscienze, Sezione di Farmacologia, Universit à degli Studi di Siena, Italy.

Free Radical Research
|January 24, 2012
PubMed
Summary

New research suggests oxygen-ozone therapy may help protect brain tissue after stroke. This preclinical study found the gas mixture effective in reverting damage, offering hope for new stroke treatments.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Research

Background:

  • Stroke is a leading cause of disability, with limited treatment options.
  • Current treatments like thrombolytic agents are only effective for a small patient percentage.
  • Reoxygenating the ischemic penumbra is crucial for reducing stroke-related morbidity.

Purpose of the Study:

  • To investigate the potential of oxygen-ozone gaseous mixture as an alternative stroke treatment.
  • To evaluate the efficacy of oxygen-ozone therapy in protecting brain tissue from ischemic damage.
  • To provide preclinical data supporting clinical trials for stroke patients.

Main Methods:

  • A preclinical study using rat hippocampal and cortical brain slices.
  • Subjecting brain slices to oxygen-glucose deprivation to mimic stroke conditions.
  • Applying an oxygen-ozone gaseous mixture to assess its therapeutic effect.

Main Results:

  • Oxygen-glucose deprivation caused significant damage to brain tissues.
  • The oxygen-ozone gaseous mixture demonstrated effectiveness in reverting this damage.
  • The treatment showed potential for neuroprotection in the preclinical model.

Conclusions:

  • Oxygen-ozone gaseous mixture is a promising therapeutic approach for stroke.
  • Preclinical findings support further investigation in clinical trials for stroke patients.
  • This therapy could offer a new strategy for reoxygenating the penumbra and reducing stroke disability.