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Updated: May 25, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
The king is dead (warfarin): direct thrombin and factor Xa inhibitors: the next Diadochian War?
Hans-Christoph Diener1, John Eikelboom, Christopher B Granger
1Department of Neurology, University Hospital Essen, Germany. h.diener@uni-essen.de
Abstract:
Atrial fibrillation is an important risk factor for stroke. New drugs for oral anticoagulation that do not exhibit the limitations of vitamin K antagonists like warfarin are under investigation. These include direct factor Xa inhibitors and direct thrombin-inhibitors. Recent studies provide promising results for apixaban, dabigatran, and rivaroxaban, including higher efficacy and significantly lower incidences of intracranial bleeds compared with warfarin. The new oral anticoagulants substances show similar results in secondary as in primary stroke prevention in patients with AF and will on the long run replace warfarin.
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