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Updated: May 25, 2026

Isolation, Characterization, and Proteomic Analysis of Plasma-Derived Extracellular Vesicles for Cardiovascular Biomarker Discovery
Published on: January 31, 2025
Costameric proteins: from benchside to future translational cardiovascular research
Giuseppina Cutroneo1, Salvatore Lentini, Angelo Favaloro
1Department of Biomorphology and Biotechnologies, School of Medicine, University of Messina, Messina, Italy.
Abstract:
Costameres encircle the myocyte perpendicular to its long axis, and comprise two protein complexes: the dystrophin-glycoprotein complex (DGC) and the vinculin-talin-integrin system. They participate in signaling functions and protect muscle cells from damage induced by workload. The behaviour of those proteins has been a focus of study starting from skeletal and smooth muscle cells to cardiomyocytes, and still represents a topical subject for cardiovascular translational research. This review summarizes the past and present novel approaches of our and other groups of work on this subject of research.
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