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Cost and effectiveness evaluation of prophylactic HPV vaccine in developing countries
Wichai Termrungruanglert1, Piyalamporn Havanond, Nipon Khemapech
1Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Summary
Implementing the human papillomavirus (HPV) vaccine nationwide in Thailand is likely cost-effective. This strategy significantly reduces HPV-related diseases and mortality rates in women.
Area of Science:
- Public Health
- Health Economics
- Epidemiology
Background:
- Cervical cancer disproportionately affects developing nations, representing 80% of global cases.
- Thailand faces a high cervical cancer incidence, making it the leading cancer among females.
Purpose of the Study:
- To assess the lifetime economic impact of human papillomavirus (HPV) infection prevention strategies.
- To evaluate the cost-effectiveness of a prophylactic quadrivalent HPV vaccine versus current practices.
Main Methods:
- A Markov simulation model was developed to analyze the incremental cost-effectiveness ratio (ICER) of HPV vaccination.
- The model incorporated disease progression, mortality, and healthcare costs within the Thai context.
- Costs and benefits were discounted at an annual rate of 3%.
Main Results:
- The ICER for the HPV vaccine was 160,649.50 baht per quality-adjusted life-year.
- HPV vaccination led to a 54.8% reduction in mortality rates.
- Incidence of cervical cancer and related conditions decreased by up to 55.1%.
Conclusions:
- Nationwide HPV vaccination coverage in girls is projected to be cost-effective in Thailand.
- The findings align with World Health Organization recommended cost-effectiveness thresholds.
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