Multimodal fundus imaging in choroidal osteoma

Area of Science:

• Ophthalmology
• Medical Imaging
• Oncology

Background:

• Choroidal osteomas are rare benign tumors of the choroid.
• Understanding their in vivo morphology is crucial for diagnosis and management.

Observation:

• A retrospective case series of three patients with choroidal osteoma was conducted.
• Multimodal imaging, including Fourier-domain optical coherence tomography (FD-OCT) and blue-light fundus autofluorescence (bAF), was utilized.

Findings:

• FD-OCT showed a latticework pattern in calcified osteomas, mimicking spongy bone.
• Decalcified areas exhibited two reflectivity patterns: lamellar hyperreflectivity and heterogeneous, mound-like hyperreflectivity.
• bAF revealed preserved fluorescence over calcified areas and reduced fluorescence over decalcified areas.

Implications:

• These imaging findings correlate with histopathology and suggest different stages of tumor evolution.
• Multimodal imaging enhances the in vivo characterization of choroidal osteomas.
• Improved understanding may impact diagnostic accuracy and treatment strategies for choroidal osteomas.