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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Chronic Obstructive Pulmonary Disease II: Emphysema01:23

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...

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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
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[Bronchiolitis obliterans: outcome in the medium term].

O Sardón1, E G Pérez-Yarza, A Aldasoro

  • 1Unidad de Neumología Infantil, Hospital Universitario Donostia, España. osardon@gmail.com

Anales De Pediatria (Barcelona, Spain : 2003)
|January 24, 2012
PubMed
Summary

Bronchiolitis obliterans (BO) in children often presents with fixed airflow obstruction. This study found lung function stability and low respiratory morbidity post-diagnosis in a pediatric cohort.

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Area of Science:

  • Pulmonology
  • Pediatric Respiratory Medicine
  • Radiology

Context:

  • Bronchiolitis obliterans (BO) is a severe obstructive lung disease following lower respiratory tract insults.
  • Geographic variations influence BO severity and outcomes.
  • Understanding pediatric BO epidemiology is crucial for targeted interventions.

Purpose:

  • To report findings from a cohort of pediatric patients diagnosed with bronchiolitis obliterans.
  • To analyze clinical characteristics, diagnostic methods, and patient outcomes.
  • To evaluate lung function changes and respiratory morbidity in children with BO.

Summary:

  • A retrospective study analyzed 22 pediatric cases of BO diagnosed between 1994 and 2011.
  • High-resolution computed tomography (HRCT) revealed mosaic attenuation and bronchiectasis.
  • Lung function tests indicated fixed airflow obstruction, increased lung volumes, and a trend toward stability post-diagnosis.

Impact:

  • The study highlights fixed airflow obstruction and generally stable lung function with low morbidity in pediatric BO.
  • HRCT and pulmonary function testing are key diagnostic tools.
  • Findings contribute to understanding the long-term respiratory health of children with BO.