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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Histone Modification

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Regulation of Metabolism

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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Histone Modification

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Updated: May 10, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Connecting threads: epigenetics and metabolism.

Sayako Katada¹, Axel Imhof, Paolo Sassone-Corsi

¹Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.

|January 24, 2012

Summary

This summary is machine-generated.

Diet impacts offspring epigenetics, suggesting histones sense metabolism. Understanding how metabolite levels control chromatin modifiers is key to translating metabolic states into stable gene expression patterns.

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Area of Science:

Epigenetics and molecular biology
Metabolic regulation
Gene expression control

Background:

Chromatin-modifying enzymes are proposed to mediate epigenetic inheritance.
Dietary effects can be transmitted epigenetically to offspring.
Histones may function as metabolic sensors, linking metabolism to gene expression.

Purpose of the Study:

To investigate the role of chromatin-modifying enzymes in epigenetic inheritance.
To explore how histones act as metabolic sensors.
To understand the mechanisms by which metabolite fluctuations influence chromatin modification.

Main Methods:

Investigating the link between diet and epigenetic modifications.
Analyzing histone modifications as indicators of metabolic state.
Studying the spatial and temporal control of chromatin modifiers by metabolites.

Main Results:

Evidence suggests diet-induced epigenetic changes are heritable.
Histones appear to translate metabolic signals into gene expression patterns.
Metabolite fluctuations dynamically regulate chromatin modifiers.

Conclusions:

Chromatin modifiers play a crucial role in epigenetic inheritance.
Histones serve as a bridge between metabolic status and gene expression.
Further research is needed to elucidate the precise mechanisms of metabolite-driven chromatin regulation.