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Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

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Whole-body PET/MRI of Pediatric Patients: The Details That Matter
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Quantifying heterogeneity in human tumours using MRI and PET.

Marie-Claude Asselin1, James P B O'Connor, Ronald Boellaard

  • 1Wolfson Molecular Imaging Centre, University of Manchester, UK.

European Journal of Cancer (Oxford, England : 1990)
|January 24, 2012
PubMed
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Tumour heterogeneity, the variation within tumors, impacts treatment. Quantitative imaging biomarkers can measure this heterogeneity in vivo, aiding drug discovery and clinical practice.

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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence

Published on: October 25, 2011

Area of Science:

  • Oncology
  • Medical Imaging
  • Biotechnology

Background:

  • Tumors exhibit significant biological heterogeneity, even within the same type and grade.
  • Regional variations in tumor cell proliferation, metabolism, and vascular structure affect therapeutic response.
  • Oxygenation, pH, and drug delivery vary within tumors, influencing treatment outcomes.

Purpose of the Study:

  • To review imaging methods for quantifying tumor heterogeneity.
  • To discuss technical challenges and metrics for estimating heterogeneity.
  • To examine clinical evidence for heterogeneity metrics in drug development and practice.

Main Methods:

  • Review of current histological and in vivo imaging techniques.
  • Analysis of quantitative imaging biomarkers for tumor structure and function.
  • Discussion of metrics for describing tumor heterogeneity.

Main Results:

  • Quantitative imaging biomarkers offer reproducible estimates of in vivo tumor heterogeneity.
  • Technical issues in quantitative heterogeneity estimation are significant.
  • Heterogeneity metrics provide valuable information in drug discovery and clinical settings.

Conclusions:

  • Imaging biomarkers are crucial for documenting and quantifying tumor heterogeneity.
  • Addressing technical challenges is key to reliable heterogeneity assessment.
  • Heterogeneity metrics enhance drug discovery and personalize cancer treatment.