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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...

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Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach
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Published on: May 23, 2025

[Paediatric malignant liver tumours].

Laurence Brugières1, Sophie Branchereau, Véronique Laithier

  • 1Institut Gustave-Roussy, département d'oncologie de l'enfant et de l'adolescent, 114, rue Édouard-Vaillant, 94805 Villejuif, France. Laurence.brugieres@igr.fr

Bulletin Du Cancer
|January 24, 2012
PubMed
Summary
This summary is machine-generated.

Malignant liver tumours are rare in children, with different types appearing at various ages. Treatment involves surgery and chemotherapy, with survival rates varying significantly by tumour type.

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Area of Science:

  • Hepatology
  • Pediatric Oncology
  • Surgical Oncology

Context:

  • Liver tumours and pseudotumours in children represent a diverse group of neoplasms.
  • Malignant liver tumours constitute less than 2% of paediatric lesions.
  • Incidence varies across paediatric age groups, with distinct tumour types prevalent in early childhood versus older children and adolescents.

Purpose:

  • To review the epidemiology, clinical presentation, and treatment strategies for malignant liver tumours in children.
  • To highlight the differences in tumour types and their age-specific incidence.
  • To discuss current treatment modalities and their outcomes.

Summary:

  • Common paediatric liver tumours include hepatoblastoma, rhabdoid tumour, hemangioendothelioma, biliary tract rhabdomyosarcoma, and mesenchymal hamartoma in infants, and hepatocellular carcinoma, focal nodular hyperplasia, and undifferentiated sarcoma in older children.
  • Treatment for malignant epithelial tumours typically involves surgical resection combined with pre- and postoperative chemotherapy, often including cisplatinum.
  • Treatment approaches are tailored based on identified risk factors.

Impact:

  • Survival rates for localized hepatoblastoma exceed 80% at three years.
  • Survival rates for hepatocellular carcinoma are less than 30% at three years.
  • The potential role of targeted therapies in managing paediatric liver malignancies requires further investigation.