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Related Experiment Video

Updated: May 25, 2026

Multi-locus Variable-number Tandem-repeat Analysis of the Fish-pathogenic Bacterium Yersinia ruckeri by Multiplex PCR and Capillary Electrophoresis

Multi-locus Variable-number Tandem-repeat Analysis of the Fish-pathogenic Bacterium Yersinia ruckeri by Multiplex PCR and Capillary Electrophoresis

Published on: June 17, 2019

Multilocus sequence typing of human and canine C. upsaliensis isolates.

B N Parsons¹, C J Porter, J H Stavisky

¹Infection Biology, School of Veterinary Science, Institute of Infection and Global Health, Leahurst Campus, Chester High Road, Neston, CH64 7TE, United Kingdom. the_trouble_with_tribbles@hotmail.com

Veterinary Microbiology

|January 24, 2012

Summary

Campylobacter upsaliensis exhibits significant genetic diversity in both dogs and humans. While dogs are a potential source of this infection, more research is needed to confirm the zoonotic risk.

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Last Updated: May 25, 2026

Multi-locus Variable-number Tandem-repeat Analysis of the Fish-pathogenic Bacterium Yersinia ruckeri by Multiplex PCR and Capillary Electrophoresis

Multi-locus Variable-number Tandem-repeat Analysis of the Fish-pathogenic Bacterium Yersinia ruckeri by Multiplex PCR and Capillary Electrophoresis

Published on: June 17, 2019

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

Area of Science:

Veterinary Microbiology
Zoonotic Diseases
Molecular Epidemiology

Background:

Campylobacter infection poses a risk to human health, with dogs identified as a potential source.
Campylobacter upsaliensis is the predominant species found in canines and has been isolated from symptomatic humans.

Purpose of the Study:

To investigate the genetic diversity of Campylobacter upsaliensis isolates from dogs and humans.
To determine the relationship between canine and human C. upsaliensis strains using Multilocus Sequence Typing (MLST).

Main Methods:

Multilocus Sequence Typing (MLST) was employed to analyze 41 C. upsaliensis isolates from dogs and 9 isolates from humans.
Sequence types (STs) and clonal complexes (CCs) were identified and compared between the two host groups.

Main Results:

A high degree of genetic diversity was observed, with 45 novel sequence types (STs) identified.
ST-104 was the only ST found in both dog and human isolates.
Four clonal complexes (CCs) contained isolates from both humans and dogs, indicating potential transmission pathways.

Conclusions:

Campylobacter upsaliensis displays considerable genetic diversity in both canine and human populations.
Dogs represent a potential zoonotic source of C. upsaliensis infection, though further epidemiological studies are required.
Expansion of the C. upsaliensis sequence database is necessary for improved strain source attribution.